教育工作经历

1999-2006年于福建农林大学完成本科和硕士学习，获得硕士学位。2006-2009年在中科院上海药物研究所沈旭研究员实验室从事抗代谢性疾病的药物研究，获得博士学位。2009-2011年在中科院福建物质结构研究所黄明东研究员组进行博士后研究，主要从事尿激酶和纤溶酶原激活物抑制因子1（PAI-1)的结构生物学研究以及以其为靶标的抗血栓、抗肿瘤药物筛选。2011年11月至2017年3月在美国霍华德休斯研究所、得州大学西南医学中心于洪涛教授实验室从事博士后研究，主要从事有丝分裂过程中关键调控蛋白的结构与功能研究，以及以这些蛋白为靶标的抗肿瘤靶向药物研究。相关研究成果发表在Nature、Cell Chemical Biology、Structure、Biochemical Pharmacology和JBC等杂志上。  

教学简介

科研简介

社会兼职

科研项目

代表性论文

1. Zhonghui Lin, Xuelian Luo, Hongtao Yu. Structural basis of cohesin cleavage by separase. Nature. 2016, 532: 131-134.

2. Zhonghui Lin#, Luying Jia#, Diana R. Tomchick, Xuelian Luo, Hongtao Yu. Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting. Structure. 2014, 22:1-12. ( #Contributed equally)

3. Zhonghui Lin#, Jan K. Jensen#, Zebin Hong, Xiaoli Shi, Lihong Hu, Peter A. Andreasen, and Mingdong Huang. Structural insight into inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist. Chemistry & Biology. 2013, 20:253-61. ( #Contributed equally)

4. Zhonghui Lin, Longguang Jiang, Cai Yuan, Jan K.Jensen, Xu Zhang, Zhipu Luo, Barbara C. Furie, Bruce Furie, Peter A. Andreasen, Mingdong Huang. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J. Biol. Chem. 2011, 286: 7027-32.  

5. Zhonghui Lin, Yu Zhang, Yinan Zhang, Hong Shen, Lihong Hu, Hualiang Jiang, and Xu Shen. Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via multi-target mechanism. Biochemical Pharmacology. 2008, 76:1251-62.

6. Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, Xue G, Yuan C, Lin L, Furie B, Flaumenhaft R, Andreasen P, Furie B, Huang M. A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase. J Cell Mol Med. 2016, 20(10):1851-60.

7. Fanglei Chen, Guiping Zhang, Zebin Hong, Zhonghui Lin, Min Lei, Mingdong Huang, Lihong Hu. Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1). Bioorg Med Chem Lett. 2014, 24(10):2379-82.

8. Zhou R, Lin ZH, Jiang CS, Gong JX, Chen LL, Guo YW, Shen X. Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation. Acta Pharmacol Sin. 2013, 34(10):1325-36.

9. Hong Ze-Bin;Lin Zhong-Hui;Gong Li-Hu;Huang Ming-Dong. Crystal structure of PAI-1 in complex with gallate. Chinese Journal of Structural Chemistry. 2013, 32(7):1005-1012.  

10. Jacky Chi Ki Ngo, Longguang Jiang, Zhonghui Lin, Cai Yuan, Zhuo Chen, Xu Zhang, Haiyang Yu, Jundong Wang, Lin Lin, Mingdong Huang. The plasminogen activation system (PAS) in pathology: use in prognosis and therapy. Curr Drug Targets. 2011, Jun 27.

11. Liu Q, Zhang Y, Lin Z, Shen H, Chen L, Hu L, Jiang H, Shen X. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol. 2010,120: 155-63.
 

获奖情况

得州大学西南医学中心药理系年度优秀博士后（2016年）
国际血栓与止血协会“第三世界科学家奖”（2011年）
中国科学院“地奥奖学金” （2009年）
中科院上海药物所研究生优秀论文二等奖（2009年）
 

其他